This expansion adds both a new Boxfish suit and Antibody cards to the game.

The Boxfish card allows a 6th player to play the game. It also adds a new type of toxicity for the advanced games : toxic by Mucus. When the Boxfish suit is the lead suit, the card with the middle value wins. If an even amount of boxfish cards is played, the card with the lowest number among the two middle cards wins the trick.

The six Antibody cards correspond to each of the suits of the game. One is given to the player which is currently losing the game at the end of each round : they get the antidote card corresponding to the suit they had the most on the previous round. In the subsequent round, if that player manages to win the most cards of that suit, they gain a Poison token.

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