Quarantine Z is a survival card game for 3-5 players. It takes place in a town, city or neighborhood that has been infested with a Zombie outbreak. The Department of Inexplicable Events has placed the area under quarantine; nothing can get out of the area until the zombie threat runs its course. One player plays as the Zombies, whose goal is to kill all Survivors. The remaining Players are Survivors, whose goal is to collect supplies and find shelter to outlast the zombie threat and the quarantine.

Survivors win if they are still alive when the Zombie Player runs out of cards in the Zombie Deck, and the Zombie Player's hand is empty. Each Survivor has 3 life, and they can be hurt by either Zombies, or other Survivors. By playing Supply cards while they are at a Shelter, Survivors "wait a week" and the Zombie player is forced to discard cards.

Survivors travel from location to location collecting Supplies and Munitions and killing or evading zombies placed in their path by the Zombie player. They must also watch out for the other Survivors who may at any time, betray them to steal their food and supplies, or use them as a distraction to save themselves.

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